Needs for Research Associate-Process R&D

Job Description

Designation: Research AssociateJob Location: BangaloreDepartment: Process R&DAbout SyngeneIncorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.Job purposeTo work on process development and synthesis of organic compounds.Key Responsibilities:
• Involvement in preparing the cost sheets for new RFP s
• Performing experiments by focusing robust process, scale up studies, engineering studies etc. to ensure the process is robust enough to scale up
• Noticing criticality of the experiments and provide valuable feedback to improve the process in-order to avoiding the batch failure
• Optimizing the chemical processes in terms of safety, robustness, and reproducibility to synthesize the target APIs for tox/clinical studies on pilot plant scale followed by large/commercial scale
• Planning the lab experiments as per the Gantt chart to meet the timeline for the projects
• Preparing the weekly update and sharing to the project leader
• Effectively utilize the available equipment s such as jacketed reactor, parallel synthesized, HPLC and RC1 to generate documents and optimization of PRD process to scalable process.
• Identifying the process related impurities and developing a robust process in-order to control the impurity or rejecting the impurity by purification method
• Ensuring 100% compliance in cGMP, GDP and data integrity
• Generating documents such as use test, solubility, halting time stability, stress experiments etc. for TTD and BMR preparations
• Interacting with AD team MoA transfer for IPC, intermediate/Finished product and raw materials
• Minimum number of experiments as per the organization requirements and generating data which should help to scale up of projects
• Analyzing the regular in-process samples in analytical lab
• Possess the knowledge and exposure to environment, health, and safety (EHS) practices
• Follow environment, health, and safety (EHS) requirements at all times in the workplace ensuring individual and lab/plant safety
• Attend training on environment, health, and safety (EHS) measures imparted company
Educational Qualification:M.Sc in Organic ChemistryExperience:3-4 years post qualification relevant experience in Process Research and Scale up, preferably CRO background .Technical/functional Skills:
• Knowledge in literature search
• Knowledge on TLC, Column Chromatography and Crystallizations
• Understand the progress of the reaction and laboratory safety practices, Understand reaction mechanisms and Named reactions
• He should be able to handle the shift operations independently
• Experience of handling hazardous chemicals like NBL, DIBAL-H and corrosive reagents.
• Hands on experience of handling of API equipment s like, Reactor, Centrifuge, Vacuum tray drier and Hydrogentaor.
• Having knowledge about handling of regulatory audits and customer audits
Behavioural Skills:
• Should have the capability to work in a team and ability to handle demonstrate a good team spirit.
• While possessing a good ability to follow instruction should also demonstrate innovative in his/her approach, good communication skills.
• Should be proactive while working on allotted responsibility.
Equal Opportunity Employer:It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
researchsafety practicespilot plantprocess researchconsumer goods