Associate scientist- Bioanalytical

Job Description

Designation: Associate scientist- BioanalyticalJob Location: BangaloreDepartment: Discovery BiologyAbout SyngeneIncorporated in 1993, Syngene International Ltd. is an innovation-focused global discovery, development and manufacturing organization providing integrated scientific services to the pharmaceutical, biotechnology, nutrition, animal health, consumer goods and specialty chemical industries around the world. Syngene s clientele includes world leaders such as Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its innovative culture is driven by the passion of its 4240- strong team of scientists who work with clients from around the world to solve their scientific problems, improve R&D productivity, speed up time to market and lower the cost of innovation.Job Purpose

• Plan and supervise routine Bioanalytical work flow to ensure deliverables/ productivity, along with verification of analytical study data for its accuracy and integrity.
• Mentor and supervise fellow scientists for method development and troubleshooting for routine as well as critical Bioanalytical work
• The candidate will be responsible for providing input into the design of experimental protocols and Bioanalytical procedures for the analysis of drug candidates in biological samples
• Follow critical organizational principles of operations like safety and data integrity

Key Responsibilities:

• Performing sample analysis for different types of ADME assays
• Processing of different matrices samples of PK studies
• Optimization of test compounds manually as well as automated on LCMS/MS
• Develop methods with the team lead for various biological matrices on LCMS/MS
• Independently handling of HPLC for UV based samples analysis.
• Documenting the lab note books online and compound management
• As an employee of Syngene, I understand that besides my functional deliverables I am also responsible for ensuring safe operations, and adherence to standards of quality and integrity set by Syngene from time to time. In light of the above, I am accountable for:

• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensuring that there are no safety non-compliances in areas that my team operates in.
• Ensuring adherence to all Syngene policies related to data integrity by all members of the team including self
• Ensuring all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self
• Reporting incidents (or near-misses) and learnings from those incidents to avoid recurrence.
• Compliance to Syngene s quality standards at all times and ensuring the same by the team members.

Educational Qualification:

• M.Sc (Biochemistry, Molecular Biology or related discipline)

Technical/functional Skills:

• Expertise in column selection, mobile phase selection, solvent preparations and sample processing techniques such as protein precipitation, liquid-liquid extraction and solid phase extraction is mandatory.
• Sample processing of New chemical entities from various in-vitro and in-vivo studies executed in Preclinical discovery by using appropriate extraction methodsShould be able to develop and validate LC-MS based qualitative/quantitative methods and apply them in routine analysis
• Should be well versed with internet-based literature search and capable of implementing the Learnings as and when required
• Candidate is expected to have basic understanding in interpretation of Mass/UV SpectraShould ensure preventative maintenance and calibration schedules of HPLC & mass spec by coordinating with vendor and support staff
• Comprehensive understanding of ADME assays and technical expertise in trouble shooting the assays.
• Should be able to deliver scientific presentation in departmental journal club and write official Project report.

Experience:

• 3-6 years post qualification

Behavioral Skills:

• Excellent verbal and written communication and interpersonal skills. Interpersonal skills Ability to work independently as well as in a team environment.
• Attention to detail, strong analytical skills and ability to work under strict timelines.

Equal Opportunity Employer:It is the policy of Syngene to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by applicable legislation or local law. In addition, Syngene will provide reasonable accommodations for qualified individuals with disabilities.,

Keyskills :
documentationvalidationsopprotocolshplcstrong analytical skillssolid phase extractionstatements of work sow