Associate Scientist - Invitro ADME

Job Description

• Overall adherence to safe practices and procedures of oneself and the teams aligned.
• Contributing to development of procedures, practices and systems that ensures safe operations and compliance to company s integrity & quality standards.
• Driving a corporate culture that promotes environment, health, and safety (EHS) mindset and operational discipline at the workplace at all times.
• Ensuring safety of self, teams and lab/plant by adhering to safety protocols and following environment, health, and safety (EHS) requirements at all times in the workplace.
• Ensure all assigned mandatory trainings related to data integrity, health, and safety measures are completed on time by all members of the team including self.
• Compliance to Syngene s quality standards at all times.
Core Purpose of the Role:
• Support the ADME team by conducting the Physicochemical assays such as solubility, Log-D, Log P and binding studies with various matrices such as plasma, tissue homogenates with highest quality.
• Interact with cross functional scientific teams and external collaborators and remain as a subject matter expert in the field of ADME sciences
• Identification of new technologies to support highly demanding ADME sciences
• Time management and multi-tasking skills to meet the demand of high-volume wave 1 ADME assays to complete multiple projects within timelines.
• Contemporaneous recording of lab activities and experiments performed, practices high level of house keeping
• Adhere to all safety rules and maintains safe workplace.
• Predominantly laboratory-based job
Key Responsibilities:
• Extensive experience in planning Physicochemical assays such as solubility, Log-D, Log P and binding assays
• Design and execute Physicochemical assays such as solubility, Log-D, Log P and PAMPA
• Design and execute binding assays in plasma, microsomes, brain and tissue homogenates assay
• Seamless coordination with BA-DMPK group execute binding studies.
• Preparation of SOP s and EOPs.
• Reporting of executed studies without any noncompliance.
• Reporting of study results clearly in the cross functional scientific meetings.
• Understanding and demonstrating responsibility for safety of self & colleagues by following all safety protocols provided by Syngene
• Adherence to all environment, health, and safety (EHS) policies & standards at all times in the workplace
• Wearing all PPE as required.
• Adherence to all procedures related to Syngene s data integrity policies
• Compliance to Syngene s quality standards at all times.
Syngene Values: All employees will consistently demonstrate alignment with our core values
• Excellence
• Integrity
• Professionalism
Experience:
• Experience in CRO (DMPK/ADME) research with 3 to 6 years
Technical/functional Skills:
• Experience in Physicochemical assays and binding assays
• Demonstrated Capability in conducting Solubility, Log D, Log P, PAMPA etc.
• Comprehensive understanding of Physicochemical and technical expertise in trouble shooting the assay.
• In depth understanding of physicochemical studies is highly desirable related to the ADME
• In depth understanding of biochemical and aspects of binding studies is highly desirable related to the ADME
• Good, demonstrated knowledge in software such as Microsoft excel and Graph pad prism
• Demonstrated cross functional leadership capabilities
• Experience with automation is desirable
Behavioral Skills:
• Demonstrate ability to be a team player.
• Commitment to deliver the study reports within the agreed timelines
• Adaptability to changes in the dynamic lab environment
• Communicate confidently with colleagues and collaborators in the meetings and presentation of study reports and evidence of publications in the PEER reviewed Journals
Educational Qualification:
• A M Pharm. in any pharmaceutical science or M Sc. in biological science.
,

Keyskills :
validationhplcsopdocumentationdata integritybinding assaysmicrosoft excel